UFC Fight Night: Chiesa vs. Lee (also known as UFC Fight Night 112) was a mixed martial arts event produced by the Ultimate Fighting Championship held on June 25, 2017, at Chesapeake Energy Arena in Oklahoma City, Oklahoma.

The event was the second that the promotion has hosted in Oklahoma City, following UFC Fight Night: Diaz vs. Guillard in September 2009.

A lightweight bout between The Ultimate Fighter: Live lightweight winner Michael Chiesa and Kevin Lee served as the event headliner.

A featherweight bout between former UFC Lightweight and Welterweight Champion B.J. Penn and Dennis Siver took place at this event. The pairing was originally booked for UFC 199. However, the bout was cancelled due to Siver being injured.

Antônio Rogério Nogueira was expected to face Ilir Latifi at the event. However, on May 17, it was announced that Nogueira pulled out due to a neck injury. Subsequently, despite having six weeks to secure a replacement opponent, promotion officials elected to remove Latifi from the event entirely.

A featherweight bout between promotional newcomers, Jared Gordon and Michel Quiñones was expected to take place at UFC 211. However, Gordon pulled out of the fight on the day before the event due to stomach illness and as a result, Quiñones was removed from the card. The pairing was rescheduled for this event.

Promotional newcomer Azamat Murzakanov was expected to face Joachim Christensen at the event. However, Murzakanov was removed from the card on June 8 for undisclosed reasons and was replaced by fellow newcomer Dominick Reyes.

At the weigh-ins, former UFC Welterweight Champion Johny Hendricks and Jared Gordon missed the required weight for their respective fights, weighing in at 188 lb and 149 lb, respectively. They were both fined 20% of their purse which went to their respective opponents, Tim Boetsch and Michel Quiñones. The bouts proceeded at catchweight.