Hudgens became a spokesperson for Neutrogena, promoting their skincare and beauty products. This marked one of her early high-profile endorsement deals.

Hudgens collaborated with the clothing brand Candie's, designing and promoting her own fashion line targeted towards young women.

Hudgens has leveraged her large social media following to collaborate with various brands and promote products. She frequently partners with fashion, beauty, and lifestyle companies.

Hudgens co-founded Know Beauty, a personalized skincare brand. The brand emphasizes DNA testing to customize skincare regimens.

Hudgens invested and partnered with Caliwater, a cactus water beverage brand.