WISE-FM is a public radio station licensed to Wise, Virginia, serving Norton, Coeburn and Clintwood in Virginia. WISE-FM is owned and operated by Virginia Polytechnic Institute and State University. The station rebroadcasts the public radio programming of Emory and Henry College radio station WEHC full-time. It also broadcasts in HD Radio; HD1 rebroadcasts the analog signal while HD2 is a feed of WVTF Music.

WISE-FM is one of three stations whose call signs spell out their city of license; the others are WACO-FM and WARE.

WISE-FM and its translators were previously full-time repeaters of Virginia Tech's Radio IQ news and public affairs network, based at WVTF in Roanoke. Effective November 12, 2022, the Virginia Tech Foundation and Emory and Henry College entered into a deal whereby WISE-FM became a repeater of the college's WEHC, based in Emory. WEHC also carries Radio IQ for part of the day, but breaks from the network in afternoons and evenings (1–4 p.m. and 6 p.m. to midnight) to air its own locally-focused talk, music, and sports programming.

In addition to the main station, WISE-FM is relayed by FM translators to widen its broadcast area.