AS220 is a non-profit community arts center located in Downtown, Providence, Rhode Island, United States. AS220 maintains four dozen artist live/work studios, around a dozen individual work studios, six rotating exhibition spaces, a main stage, a black box theater, a dance studio, a print shop, a community darkroom, a digital media lab, a fabrication lab, an organization-run bar and restaurant, a youth recording studio, and a youth program (AS220 Youth; formerly named the Broad Street Studio). AS220 is an unjuried and uncensored forum for the arts, open to all ages.

AS220 was founded in 1985 by Umberto Crenca, alongside Susan Clausen and Scott Seabolt as a space for artists and performers to exhibit their work in an uncensored and unjuried venue. Umberto and a group of artists had been frustrated by conditions in the Rhode Island arts community which made access and success difficult for those outside the Rhode Island School of Design and initiatives backed by local government. In response, they wrote a manifesto and formed AS220 with an emphasis on openness and access.

AS220 began as an unofficial artists' space at 220 Weybosset Street in downtown Providence, above the Providence Performing Arts Center, incorporating its address into its name. It grew to a collection of seven studios, a gallery, and a performance stage and expanded to Richmond Street.

In 1992, AS220 acquired its own 21,000-square-foot (2,000 m²) building on 95-121 Empire Street, which it renovated in order to create a space for a mixed-use arts center including resident artists, a performance space and gallery, and resident companies like Groundwerx Dance Company and Perishable Theater. The development of the Empire Street facility is credited in part with the creation of an arts and entertainment District in Providence. In 2015, after serving 30 years as artistic director, Crenca transferred his leadership role to Shey Rivera Ríos .

In 2000, AS220 established the Broad Street Studio. Between 2003 and 2006, they launched a Capital Campaign which raised $2 million to improve the Empire Street Complex, including the creation of the AS220 Bar and Restaurant.

In 2005, AS220 purchased the Dreyfus Hotel, a 24,000-square-foot (2,200 m²) building on the corner of Washington and Mathewson Streets in downtown Providence. It opened in May 2007 upon the completion of renovations and today is home to fourteen residential studios and four work rental studios, the AS220 administrative offices, and its Project Space art gallery.

In June 2011, AS220 opened its newly renovated Mercantile Block building at 131 Washington Street in Downtown Providence, which it had purchased in 2008. It houses AS220 Industries, comprising the AS220 Community Printshop, AS220 Labs, and AS220 Media Arts. It also includes live and work artist studios, office space for local non-profits, and street-level retail space for local businesses.

AS220 hosts the bi-annual professional development program Practice-Practice for arts administrators around the country and globally.