Wadi Natuf (Arabic: وادي الناطوف, Wadi al-Natuf / Wadi en-Natuf) or Nahal Natuf (Hebrew: נחל נטוף) is a wadi (seasonal stream) in the West Bank and Israel, rising in the north of the Ramallah and al-Bireh Governorate of Palestine, crossing into Israel north of Modi'in and discharging into the Ayalon River at the Ben Gurion Airport.

The Natufian culture–an archaeological culture of the Epipaleolithic period in the Levant region–is named after the wadi. Along with the Shuqba Cave, which opens onto its northern bank, Wadi Natuf has been nominated as a tentative UNESCO World Heritage Site in the State of Palestine.