West Memphis is the most populous city in Crittenden County, Arkansas, United States. The population was 24,520 at the 2020 census, ranking it as the state's 20th largest city. It is part of the Memphis metropolitan area, and is located directly across the Mississippi River from Memphis, Tennessee.

Explorers from both Spain and France visited the area near West Memphis. Among those explorers were Hernando de Soto and his men from Spain and Father Jacques Marquette and Louis Jolliet from France. By the time French hunters and explorers entered the region, the Mississippian towns and other settlements had been abandoned. The original site of West Memphis came from Spanish land grants issued during the 1790s. Grants were given to Benjamin Fooy, John Henry Fooy, and Isaac Fooy in the Hopefield (Crittenden County) area and to William McKenney in the Bridgeport-West Memphis area.

In the summer of 1541, Spanish explorer Hernando De Soto crossed the Mississippi River into what is now Crittenden County with an army of over 300 conquistadors and almost as many captured Native American slaves. The Spanish found the land to be the most densely populated that they had seen since starting their journey on the Florida coast, two years earlier. The Spanish expedition departed Arkansas two years later, leaving behind numerous Old World diseases. It was 130 years before Europeans visited this region again. The French expedition of Joliet and Marquette in 1673 found none of the towns or people that the Spanish had documented; all that remained were the many mounds that still dot the landscape along the rivers and creeks. The original inhabitants, like the later settlers, were drawn to this region because of its fertile river bottom soil, abundant game, and thick forest.

The earliest recorded immigrant to the area was Benjamin Fooy, a native of Holland, who was sent in 1795 by the Spanish governor of the large area claimed by Spain to establish a settlement on the Mississippi River. He chose a location across the river from present-day Memphis. In 1797, the Spanish established Campo de la Esperanza, which was a small fort along the Mississippi River. The Spanish abandoned the fort in 1802 and the area took its English translation "Field of Hope", which eventually became known as Hopefield shortly after the United States took possession of the Louisiana Territory.

Crittenden County is bounded on the east by the Mississippi River and was established in 1825, eleven years before Arkansas became a state. Named after Robert Crittenden, the first secretary of the Arkansas Territory, the county had a population of 1,272 in 1830. Hopefield became the eastern terminal for the Memphis and Little Rock Railroad in 1857. However, the Civil War forced a halt to track construction just east of the St. Francis River in 1861.

During the summer of 1862, Memphis fell into the hands of the Union forces. Most Confederate soldiers were ferried across the river to Hopefield, Arkansas, and surrounding farms. Many of these soldiers were moved on to other battle fronts, but some remained to harass the Union forces and disrupt river traffic. This became such a problem that on February 19, 1863, four companies of Federal forces burned down the entire town. The town of Hopefield was rebuilt after the war but never regained the prominence it once held in Crittenden County. After the St. Francis Levee District began the levee system in the Arkansas Delta during the 1890s, what little remained of Hopefield became part of the Mississippi River flood plain and was washed away.

An early settlement that was established for ferry operations between Memphis and Arkansas in the early 1880s was given the name West Memphis. This small settlement, located directly south of the present day Memphis & Arkansas Bridge, never incorporated and died out shortly after ferry traffic ceased due to the completion of the Frisco Bridge across the Mississippi River in 1892. In addition to its lost ferry operations, this area, in the same fashion as its northern neighbor Hopefield, became part of the Mississippi River flood plain in the 1890s.

The entire area usually flooded in the spring until the St. Francis Levee District was established in 1893. However, private landowners along the Mississippi River built levees that were only three or four feet high. In 1912 and 1913, the St. Francis main levee broke, flooding the area from the Mississippi River to Forrest City in St. Francis County. The flood of 1913 was the last time the levee broke in Crittenden County.