The 1906 Boston Americans season was the sixth season for the professional baseball franchise that later became known as the Boston Red Sox. The Americans finished last in the eight-team American League (AL) with a record of 49 wins and 105 losses, 45+1⁄2 games behind the Chicago White Sox. The team played its home games at Huntington Avenue Grounds.

Prior to the regular season, the team held spring training in Macon, Georgia.

The offense was led by Chick Stahl with 51 RBIs and four home runs, and Myron "Moose" Grimshaw with a .290 batting average. The pitching staff was led by Cy Young, who made 39 appearances (34 starts) and pitched 28 complete games with a 13–21 record and 3.19 ERA, while striking out 140 in 287+2⁄3 innings. Jesse Tannehill was the only member of the starting rotation with winning record, at 13–11, while Bill Dinneen had the rotation's lowest ERA, at 2.92.

The team had one game end in a tie; April 18 vs. New York Highlanders. Tie games are not counted in league standings, but player statistics during tie games are counted.

Source:

Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in

Note: G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in

Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts