The 1958 NFL draft had its first four rounds held on December 2, 1957, and its final twenty-six rounds on January 28, 1958. Both sessions were held at the Warwick Hotel in Philadelphia.

This was the 12th and final year in which the first overall pick was a "lottery bonus". The Chicago Cardinals were automatically awarded the pick because it was the only team left that had not won the draft lottery yet. The Cardinals used the first pick to select quarterback King Hill.