The 1959 NBA All Star Game was an exhibition basketball held on January 23, 1959, at the Olympia Stadium in Detroit, home of the Detroit Pistons. It was the ninth edition of the National Basketball Association (NBA) All-Star Game, held during the 1958–59 NBA season. It was the first and only All-Star Game held in Detroit to date—though the Pistons later hosted the 1979 game in the suburb of Pontiac, Michigan—and the second hosted by the Pistons franchise, following the 1953 game held in Fort Wayne, Indiana, when the team was known as the Fort Wayne Pistons.

The coaches were the Boston Celtics' Red Auerbach for the East and the St. Louis Hawks' Ed Macauley for the West, as both teams had led their respective divisions prior to the game. The West won the game 124–108. Elgin Baylor and Bob Pettit were named the Most Valuable Players, marking the first time in league history that two players shared the award in the same game.

Head Coach: Ed Macauley, St. Louis Hawks

Head Coach: Red Auerbach, Boston Celtics