The 1981 Boston Red Sox season was the 81st season in the franchise's Major League Baseball history. Due to the 1981 Major League Baseball strike, play during the regular season was suspended for 50 days, and the season was split into two halves, with playoff teams determined by records from each half of the season. In the first half of the season, the Red Sox finished fifth in the American League East with a record of 30 wins and 26 losses, four games behind the New York Yankees. In the second half of the season, the Red Sox finished tied for second in the division with a record of 29 wins and 23 losses, 1+1⁄2 games behind the Milwaukee Brewers. The Red Sox' overall record for the season was 59–49.

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The Chicago White Sox defeated the Red Sox on Opening Day, 5–3. It was the first game that Carlton Fisk played for the White Sox, after 11 seasons with the Red Sox; Fisk hit a three-run home run in the eighth inning.

Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; BB = Walks; AVG = Batting average; SLG = Slugging average

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Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Runs allowed; ER = Earned runs allowed; BB = Walks allowed; SO = Strikeouts

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