The 2000 Duke Blue Devils football team represented Duke University as a member of the Atlantic Coast Conference (ACC) during the 2000 NCAA Division I-A football season. Led by second-year head coach Carl Franks, the Blue Devils compiled an overall record of 0–11 with a mark of 0–8 in conference play, placing last out of nine teams in the ACC. The team played home games at Wallace Wade Stadium in Durham, North Carolina.