The 2008 Coke Zero 400 Powered by Coca-Cola was the eighteenth race of the 2008 NASCAR Sprint Cup season, marking the official halfway point of the season.

Daytona International Speedway is one of three superspeedways to hold NASCAR races, the other two being Atlanta Motor Speedway and Talladega Superspeedway. The standard track at Daytona International Speedway is a four-turn superspeedway that is 2.5 miles (4.0 km) long. The track's turns are banked at 31 degrees, while the front stretch, the location of the finish line, is banked at 18 degrees.

This race was held on July 5 of that year at Daytona International Speedway in Daytona Beach, Florida, and was the third race utilizing restrictor plates this season. TNT's air time began at 6:30 PM US EDT, and MRN with Sirius Satellite Radio carried the radio broadcast beginning at 7:15 PM US EDT.

Paul Menard won his first pole of his career in Sprint Cup racing, edging his teammate, Mark Martin out for the honor.

OP: qualified via owners points

PC: qualified as past champion

PR: provisional

QR: via qualifying race