The 2010–11 UEFA Champions League was the 56th season of Europe's premier club football tournament organised by UEFA, and the 19th under the UEFA Champions League format. The final was held at Wembley Stadium in London on 28 May 2011, where Barcelona defeated Manchester United 3–1.

Internazionale were the defending champions, but were eliminated by Schalke 04 in the quarter-finals. As winners, Barcelona earned berths in the 2011 UEFA Super Cup and the 2011 FIFA Club World Cup.

A total of 76 teams participated in the 2010–11 Champions League, from 52 UEFA associations (Liechtenstein organised no domestic league competition). Associations were allocated places according to their 2009 UEFA country coefficient, which took into account their performance in European competitions from 2004–05 to 2008–09.

Below is the qualification scheme for the 2010–11 UEFA Champions League:

Since the winners of the 2009–10 UEFA Champions League, Internazionale, obtained a place in the group stage through their domestic league placing, the reserved title holder spot in the group stage was effectively vacated. To compensate:

The labels in the parentheses show how each team qualified for the place of its starting round:

All draws held at UEFA headquarters in Nyon, Switzerland unless stated otherwise.

The draws for the qualifying rounds, the play-off round and the group stage were all seeded based on the 2010 UEFA club coefficients. The coefficients were calculated on the basis of a combination of 20% of the value of the respective national association's coefficient for the period from 2005–06 to 2009–10 inclusive and the clubs' individual performances in the UEFA club competitions during the same period. Clubs were ordered by their coefficients and then divided into pots as required.