The 2012–13 Copa Chile, (officially known as Copa Chile MTS 2012/13 because of its sponsorship), is the 33rd edition of the Copa Chile, the country's national cup tournament. The competition started on June 23, 2012, with the First Round and concludes on May 8, 2013, with the Final. The winner qualifies for the 2013 Copa Sudamericana.

A total 46 clubs were accepted for the competition. The teams for this edition are the teams from the Primera División, Primera B, Segunda División, and selected Tercera División teams.

This round comprised the 2012 Primera B teams, 6 Segunda División and 8 Tercera División teams.

The Second Round marks the beginning of the competition for Primera División teams. This round comprised the winners of the First Round and the 2012 Primera División teams. Every team plays home and away against every other team in its group. The best 2 teams from each group advance to the next round.

Universidad Católica won 11–3 on aggregate.

Universidad de Chile won 5–0 on aggregate.

Cobreloa won 4–3 on aggregate.

Unión Española won 5–2 on aggregate.