The 2012 Copa Venezuela was the 43rd staging of the Copa Venezuela. The winner qualified for the 2013 Copa Sudamericana.
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Arroceros de Calabozo | 1–9 | Atlético Venezuela | 1–3 | 0–6 |
| Estrella Roja | 3–3 (a) | Deportivo Anzoátegui | 3–1 | 0–2 |
| Deportivo Metropolitano | 1–2 | Real Esppor Club | 0–1 | 1–1 |
| Angostura FC | 2–1 | Monagas SC | 2–0 | 0–1 |
| UCV FC | 1–5 | Aragua FC | 1–0 | 0–5 |
| Tucanes de Amazonas | 1–1 (3–4 p) | Deportivo Petare | 1–0 | 0–1 |
| Atlético Miranda | 6–7 | Caracas FC | 4–2 | 2–5 |
| Llaneros de Guanare | 0–3 | Zamora FC | 0–2 | 0–1 |
| Deportivo San Antonio | 1–3 | Deportivo Táchira | 0–0 | 1–3 |
| Lotería del Táchira | 1–5 | Atlético El Vigía | 0–0 | 1–5 |
| Guaraní SC | 1–1 (4–2 p) | Portuguesa FC | 1–0 | 0–1 |
| Trujillanos FC | 3–2 | Zulia FC | 2–2 | 1–0 |
| Carabobo FC | 2–3 | Yaracuyanos FC | 2–2 | 0–1 |
| Ureña SC | 0–0 (2–4 p) | Estudiantes de Mérida | 0–0 | 0–0 |
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Mineros de Guayana | 0–0 (3–4 p) | Caracas FC | 0–0 | 0–0 |
| Deportivo Petare | 1–4 | Atlético Venezuela | 1–2 | 0–2 |
| Aragua FC | 4–4 (5–6 p) | Deportivo Anzoátegui | 2–2 | 2–2 |
| Angostura FC | 1–9 | Real Esppor Club | 1–3 | 0–6 |
| CD Lara | 3–7 | Estudiantes de Mérida | 1–2 | 2–5 |
| Yaracuyanos FC | 2–4 | Zamora FC | 1–1 | 1–3 |
| Trujillanos FC | 1–1 (a) | Deportivo Táchira | 0–0 | 1–1 |
| Guaraní SC | 2–2 (a) | Atlético El Vigía | 0–1 | 2–1 |
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Caracas FC | 1–1 (2–3 p) | Real Esppor Club | 0–1 | 1–0 |
| Deportivo Anzoátegui | 3–2 | Atlético Venezuela | 3–1 | 0–1 |
| Guaraní SC | 2–5 | Estudiantes de Mérida | 0–1 | 2–4 |
| Trujillanos FC | 2–4 | Zamora FC | 1–2 | 1–2 |
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Real Esppor Club | 1–3 | Deportivo Anzoátegui | 0–0 | 1–3 |
| Zamora FC | 2–4 | Estudiantes de Mérida | 2–3 | 0–1 |
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Deportivo Anzoátegui | 2–1 | Estudiantes de Mérida | 1–1 | 1–0 |
