The 2013 Setanta Sports Cup was the eighth staging of the Setanta Sports Cup, an annual football competition featuring clubs from Northern Ireland and Republic of Ireland. It commenced on 11 February 2013 and ended on 11 May 2013 with the final played at the Tallaght Stadium, Dublin.

Crusaders were the defending champions, after they defeated Derry City 5–4 on penalties in the 2012 final, when the match ended 2–2 after extra time. However, this season they went out 4–1 on aggregate in the quarter-finals to Cork City. Shamrock Rovers were the eventual winners for the second time overall, following a comfortable 7–1 win over Drogheda United in the final. This season's competition was notable for the fact that all four semi-finalists represented the Republic of Ireland. It was also the sixth time in the eight competitions played thus far that the winner had been a League of Ireland club.

The following clubs qualified to take part in this year's competition. The eight unseeded clubs entered in the first round, while the four seeded clubs entered in the quarter-finals.

The first round draw was made on 6 December 2012. Four League of Ireland and four IFA Premiership clubs played each other in the first round over two games with the winners qualifying for the quarter-finals. The first legs were played on 11 February 2013 and the second legs were played on 18 February 2013.

Shamrock Rovers won 2−1 on aggregate.

Glentoran won 1−0 on aggregate.

Cork City won 6−2 on aggregate.

Drogheda United won 8−2 on aggregate.