2017 AFC Champions League knockout stage

The 2017 AFC Champions League knockout stage was played from 22 May to 25 November 2017. A total of 16 teams competed in the knockout stage to decide the champions of the 2017 AFC Champions League.

The winners and runners-up of each of the eight groups in the group stage advanced to the round of 16, with both West Region (Groups A–D) and East Region (Groups E–H) having eight qualified teams.

In the knockout stage, the 16 teams played a single-elimination tournament, with the teams split into the two regions until the final. Each tie was played on a home-and-away two-legged basis. The away goals rule, extra time (away goals would not apply in extra time) and penalty shoot-out were used to decide the winner if necessary (Regulations Article 11.3).

The schedule of each round was as follows. Matches in the West Region were played on Mondays and Tuesdays, while matches in the East Region were played on Tuesdays and Wednesdays.

The bracket of the knockout stage was determined as follows:

The bracket was decided after the draw for the knockout stage, which was held on 6 June 2017, 16:00 MYT (UTC+8), at the JW Marriott Hotel Kuala Lumpur in Kuala Lumpur, Malaysia.

In the round of 16, the winners of one group played the runners-up of another group from the same region, with the matchups determined by the group stage draw, and the group winners hosting the second leg.

Al-Ain won 6–2 on aggregate.