Beginning on the afternoon of September 15, 2017, a series of protests took place in St. Louis, Missouri, following the acquittal of former St. Louis police officer Jason Stockley in the shooting of Anthony Lamar Smith, a black man. Over 160 people were arrested during the first three days of demonstrations, with largely peaceful protests. There has been significant criticism around the police and governmental response to protests, resulting in lawsuits from the ACLU.

Roughly 200-300 demonstrators assembled in downtown St. Louis near the city courthouse. The protests were mostly peaceful. Police used pepper spray to drive back protesters on at least two occasions: after protesters responded angrily to the approach of buses filled with police in tactical armor (riot gear), and after individuals mounted an abandoned police vehicle and damaged its windshield.

Demonstrations later moved to the Central West End neighborhood, where they swelled to over 1,000 people. They were peaceful until about 9:45 pm, after protesters made their way to the home of mayor Lyda Krewson. Despite urgings from demonstration leaders, at least one protester put a rock through the mayor's window. The mayor is believed not to have been home. Although most demonstrators dispersed immediately, police deployed pepper spray and tear gas, driving back remaining demonstrators and onlookers through the Central West End's commercial area. There, angered protesters damaged several businesses.

A total of 33 people, 32 of whom were local, were arrested and charged with crimes ranging from peace disturbance to destruction of property. The US Justice Department announced that no federal investigation will take place.

On the afternoon of September 16, protesters marched through a shopping center in the St. Louis suburb of Des Peres and blocked a road. As the sun set a peaceful march made its way through the St. Louis suburb of University City. As night fell, however, demonstrators threw projectiles at police and smashed storefront windows as police drove them down Delmar Boulevard. 23 businesses and a police vehicle were damaged. Police made nine arrests.

About 1,000 people protested outside police headquarters in downtown St. Louis. The event was peaceful until a small group of protesters started smashing the windows of a Marriott hotel and other businesses. Police arrested 123 people. Police also said unknown chemical substances were thrown at them and that an officer on bike was taken to the hospital for non-life-threatening injuries. Among those arrested included an undercover St. Louis police officer, a Getty Images photojournalist, and an Air Force lieutenant.

Protestors gathered outside the downtown St. Louis jail.

Police in Richmond Heights shut down the St. Louis Galleria after a group of protesters blocked the intersection of Brentwood Boulevard and Galleria Parkway. Protests started outside Busch Stadium in downtown St Louis, as a Billy Joel concert took place.