The 2018 CAF Confederation Cup (officially the 2018 Total CAF Confederation Cup for sponsorship reasons) was the 15th edition of Africa's secondary club football tournament organized by the Confederation of African Football (CAF), under the current CAF Confederation Cup title after the merger of CAF Cup and African Cup Winners' Cup.

Raja Casablanca won the title for the first time, defeating AS Vita Club in the final, and earned the right to play against the winners of the 2018 CAF Champions League in the 2019 CAF Super Cup.

TP Mazembe were the two-time defending champions, but as they qualified for the 2018 CAF Champions League and reached the group stage, they were not able to defend their title.

All 56 CAF member associations may enter the CAF Confederation Cup, with the 12 highest ranked associations according to their CAF 5-year ranking eligible to enter two teams in the competition. As a result, theoretically a maximum of 68 teams could enter the tournament (plus 16 teams eliminated from the CAF Champions League which enter the play-off round) – although this level has never been reached.

For the 2018 CAF Confederation Cup, the CAF uses the 2012–2016 CAF 5-year ranking, which calculates points for each entrant association based on their clubs' performance over those 5 years in the CAF Champions League and CAF Confederation Cup. The criteria for points are the following:

The points are multiplied by a coefficient according to the year as follows:

The following 54 teams from 42 associations entered the competition.

Associations are shown according to their 2012–2016 CAF 5-year ranking – those with a ranking score have their rank and score indicated.