The 2018 Pennzoil 400 was a Monster Energy NASCAR Cup Series race held on March 4, 2018, at Las Vegas Motor Speedway in Las Vegas. Contested over 267 laps on the 1.5 mi (2.4 km) asphalt intermediate speedway, it was the third race of the 2018 Monster Energy NASCAR Cup Series season.

Las Vegas Motor Speedway, located in Clark County, Nevada outside the Las Vegas city limits and about 15 miles northeast of the Las Vegas Strip, is a 1,200-acre (490 ha) complex of multiple tracks for motorsports racing. The complex is owned by Speedway Motorsports, Inc., which is headquartered in Charlotte, North Carolina.

Kyle Larson was the fastest in the first practice session with a time of 28.323 seconds and a speed of 190.658 mph (306.834 km/h).

Ryan Blaney scored the pole for the race with a time of 28.200 and a speed of 191.489 mph (308.172 km/h).

Kyle Larson was the fastest in the second practice session with a time of 28.791 seconds and a speed of 187.559 mph (301.847 km/h).

Ryan Blaney was the fastest in the final practice session with a time of 28.963 seconds and a speed of 186.445 mph (300.054 km/h).

Ryan Blaney led the field to the green flag at 3:46 p.m. Blaney led a total of one lap, and Kevin Harvick took the lead on lap 2, and led 37 laps, but then Michael McDowell took the lead on lap 39 and led 11 laps, and Kevin Harvick regained the lead on lap 49 and led the 80-lap first stage. He finished 3.6 seconds in front of Martin Truex Jr., leading 68 of the 80 laps. Also in the top five were Kyle Larson, Ryan Blaney and Joey Logano. The first caution of the race flew for conclusion of stage 1.

The race restarted on lap 89, Kyle Busch took the lead on lap 122, and led 4 laps, but then Kevin Harvick regained the lead on lap 126 and dominated the race in its second stage, winning by 5.3 seconds over Ryan Blaney. Following were Kyle Larson, Joey Logano and Kyle Busch. Harvick led 76 of the stage’s 80 laps. The second caution of the race flew for conclusion of stage 2.