| 2018 San Luis Open Challenger Tour | |
|---|---|
| Date | 27 March – 1 April |
| Edition | 25th |
| Draw | 32S / 16D |
| Surface | Clay |
| Location | San Luis Potosí, Mexico |
| Champions | |
| Singles | |
 Marcelo Arévalo | |
| Doubles | |
Marcelo Arévalo /  Miguel Ángel Reyes-Varela | |
The 2018 San Luis Open Challenger Tour was a professional tennis tournament played on hard courts. It was the 25th edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in San Luis Potosí, Mexico between 27 March and 1 April 2018.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ITA
|
Paolo Lorenzi | 57 | 1 |
 AUT
|
Gerald Melzer | 113 | 2 |
 GER
|
Yannick Hanfmann | 124 | 3 |
 BRA
|
Thomaz Bellucci | 135 | 4 |
 DOM
|
Víctor Estrella Burgos | 152 | 5 |
 USA
|
Evan King | 188 | 6 |
| USA
|
Mitchell Krueger | 207 | 7 |
 SRB
|
Peđa Krstin | 208 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Marcelo Arévalo def. Roberto Cid Subervi 6–3, 6–7(3–7), 6–4. Marcelo Arévalo / Miguel Ángel Reyes-Varela def. 
Jay Clarke / Kevin Krawietz 6–1, 6–4.
