The 2019 Coca-Cola 600, the 60th running of the event, was a Monster Energy NASCAR Cup Series race held on May 26, 2019, at Charlotte Motor Speedway in Concord, North Carolina. Contested over 400 laps on the 1.5 mile (2.42 km) asphalt speedway, it was the 13th race of the 2019 Monster Energy NASCAR Cup Series season. Martin Truex Jr. won his fourth race of the season, second Coca-Cola 600, and 22nd career victory overall.

The race was held at Charlotte Motor Speedway, which is located in Concord, North Carolina. The speedway complex includes a 1.5-mile (2.4 km) quad-oval track that will be utilized for the race, as well as a dragstrip and a dirt track. The speedway was built in 1959 by Bruton Smith and is considered the home track for NASCAR with many race teams based in the Charlotte metropolitan area. The track is owned and operated by Speedway Motorsports Inc. (SMI) with Marcus G. Smith serving as track president.

For the race, every car on track would sport a fallen military member tribute on their cars.

Daniel Hemric was the fastest in the first practice session with a time of 29.542 seconds and a speed of 182.791 mph (294.174 km/h).

William Byron scored the pole for the race with a time of 29.440 and a speed of 183.424 mph (295.192 km/h).

Daniel Suárez was the fastest in the second practice session with a time of 29.647 seconds and a speed of 182.143 mph (293.131 km/h).

Daniel Suárez was the fastest in the final practice session with a time of 29.883 seconds and a speed of 180.705 mph (290.817 km/h).

Stage 1 Laps: 100