On 29 November 2019, five people were stabbed, two of them fatally, in Central London. The attacker, Usman Khan, had been released from prison in 2018 on licence after serving a sentence for terrorist offences.

Since Khan was considered a "success story" for a Cambridge University rehabilitation programme, and was featured as a case study by the University, he was attending an offender rehabilitation conference in Fishmongers' Hall. He threatened to detonate what turned out to be a fake suicide vest and started attacking people with two knives taped to his wrists, killing two of the conference participants by stabbing them in the chest. Several people fought back, some attacking Khan with a fire extinguisher, a pike and a narwhal tusk as he fled the building and emerged on to London Bridge, where he was partially disarmed by a plain-clothes police officer. He was restrained by members of the public until additional police officers arrived, pulled away those restraining him, and shot him. Khan died at the scene.

A conference on offender rehabilitation was held on 29 November 2019 in Fishmongers' Hall, at the northern end of London Bridge, in the City of London, to celebrate the fifth anniversary of Learning Together, a programme run by the Cambridge Institute of Criminology to help offenders reintegrate into society following their release from prison. Learning Together was set up in 2014 by University of Cambridge academics Ruth Armstrong and Amy Ludlow from the Faculty of Law and Institute of Criminology to "bring together people in criminal justice and higher education institutions to study alongside each other in inclusive and transformative learning communities" to enable students and prisoners to work together.

Former prisoner Usman Khan had been invited to the conference as a previous participant in the programme, and although banned from entering London under the terms of his release, he was granted a one-day exemption to attend.

At 13:58 on 29 November, the police were called to Fishmongers' Hall after Khan, wearing a fake suicide vest, threatened to blow up the hall. Holding two kitchen knives taped to his wrists, he began stabbing people inside the building. Several fought back, including a Polish kitchen porter, Łukasz Koczocik, who fought Khan off with an ornamental spear, a South African-born Londoner, Darryn Frost, who grabbed a 1.5-metre-long (4.9 ft) narwhal tusk from the wall to use as a weapon, former prisoner John Crilly, and Steven Gallant, a convicted murderer attending the conference on day release from prison, after participating in the Learning Together programme. Khan fled and began stabbing pedestrians outside on the north side of the bridge.

Several people were injured before members of the public, including a tour guide and a plain-clothes British Transport Police officer, later seen walking away with a knife, restrained and disarmed Khan on the bridge. One of the people who stepped in to fight the attacker drove him back by spraying a fire extinguisher.

Armed officers of the City of London Police arrived at 14:03 and surrounded the attacker, who at the time was being restrained by a Ministry of Justice communications worker attending the rehabilitation meeting. The officers pulled this person away to provide a clear shot, before one fired twice. At 14:10, Khan started to get up; he was then shot 10 further times by six firearms officers. Khan had not been secured after the initial shooting due to the suicide vest. Khan died at the scene.

A Transport for London bus which had stopped adjacent to the site of the shooting was found to have damage to both its front and rear windows, possibly caused, according to the Metropolitan Police, by a ricocheting bullet.