The 2019 Madrid Open (sponsored by Mutua) was a professional tennis tournament played on outdoor clay courts at the Park Manzanares in Madrid, Spain from 3–12 May 2019. It was the 18th edition of the event on the ATP Tour and 11th on the WTA Tour. It was classified as an ATP Tour Masters 1000 event on the 2019 ATP Tour and a Premier Mandatory event on the 2019 WTA Tour. This event was the final professional tennis tournament for Spanish player David Ferrer, who received a wildcard into the singles draw.

Ion Țiriac, the event owner, announced in April 2019 that he has extended his sponsorship contract of the Mutua Madrid Open for 10 additional years, until 2031. Because he agreed to continue in Madrid, Țiriac will receive more than 30 million euros from the city of Madrid in the coming years.

The following are the seeded players. Seedings are based on ATP rankings as of 29 April 2019. Rankings and points before are as of 6 May 2019.

† The player did not qualify for the tournament in 2018. Accordingly, points for his 18th best result are deducted instead.

The following players would have been seeded, but they withdrew from the event.

‡ The player is entitled to use an exemption to skip the tournament and substitute his 18th best result (45 points) in its stead.

The following players received wildcards into the main draw:

The following player received entry using a protected ranking into the main draw: