The 2020 12 Hours of Sebring (formally known as the 68th Mobil 1 Twelve Hours of Sebring Presented by Advance Auto Parts) was an endurance sports car race held at Sebring International Raceway near Sebring, Florida from 11–14 November 2020, after being postponed from its original date on 14–15 March 2020 due to the COVID-19 outbreak. The race was the final round of the 2020 WeatherTech SportsCar Championship, as well as the final round of the Michelin Endurance Cup. Action Express Racing entered as the defending overall winners of the 12-hour event.

The 2020 12 Hours of Sebring event was supposed to run in conjunction with the 2020 1000 Miles of Sebring, held on the Friday before the 12 Hours of Sebring. The two events usually are run in conjunction with each other as an agreement between the International Motor Sports Association (IMSA), the governing body of the WeatherTech SportsCar Championship, and the FIA, to be a joint weekend, known colloquially as “Super Sebring.” The first joint weekend between the two events was run a year prior in 2019, to massive success, providing some of the largest attendance figures ever recorded in the history of the 12 Hours of Sebring. Initially announced on a one-year deal, the success of the 2019 Super Sebring would lead to confirmation that the 1000 Miles of Sebring and 12 Hours of Sebring would run together again for the following year, however due to travel restrictions brought about by COVID-19 the 1000 Miles of Sebring would not return until 2022.

Then International Motor Sports Association's (IMSA) president Scott Atherton confirmed the race was part of the schedule for the 2020 IMSA SportsCar Championship (IMSA SCC) in August 2019. It was the seventh consecutive year it was part of the IMSA SCC, and the 68th 12 Hours of Sebring. The event was originally scheduled to be held at the 17-turn, 3.741-mile (6.021 km) Sebring International Raceway in Sebring, Florida on March 15, 2020, however due to travel restrictions brought about by COVID-19, the race was postponed to November 14, 2020. As a result, the 12 Hours of Sebring became the eleventh and final round of the 2020 season and the fourth event of the Michelin Endurance Cup (MEC). Additionally, the event clashed with the FIA World Endurance Championship round at Bahrain and the GT World Challenge Europe round at Circuit Paul Ricard.

Before the race, Helio Castroneves and Ricky Taylor led the DPi Drivers' Championship with 242 points, ahead of Ryan Briscoe and Renger van der Zande with 240 points, and Pipo Derani with 233 points. With 161 points, Patrick Kelly led the LMP2 Drivers' Championship, ahead of Simon Trummer with 126 points. Antonio García and Jordan Taylor led the GTLM Drivers' Championship with 325 points, ahead of Oliver Gavin and Tommy Milner with 290 points. In GTD, Mario Farnbacher and Matt McMurry led the Drivers' Championship, 7 points ahead of Ryan Hardwick and Patrick Long in second, and Aaron Telitz in third with 248 points. Cadillac, Chevrolet, and Acura were leading their respective Manufacturers' Championships, while Acura Team Penske, PR1/Mathiasen Motorsports, Corvette Racing, and Meyer Shank Racing with Curb-Agajanian each led their own Teams' Championships.

A total of 31 cars took part in the event split across four classes. 8 cars were entered in DPi, 4 in LMP2, 6 in GTLM, and 13 in GTD. In DPi, Gabby Chaves subbed for Filipe Albuquerque in the Whelen Engineering Racing entry due to a clash with the FIA World Endurance Championship round at Bahrain. Scott Andrews joined Stephen Simpson and Matheus Leist in the #85 JDC-Miller MotorSports entry. In LMP2, Tower Motorsport By Starworks, Performance Tech Motorsports, and Inter Europol Competition returned after skipping the previous event at Laguna Seca. Guy Cosmo and Patrick Byrne joined Don Yount in the Performance Tech Motorsports entry. In GTLM, Neel Jani subbed for Mathieu Jaminet in the #912 Porsche GT Team entry due to a clash with the GT World Challenge Europe round at Circuit Paul Ricard. Earl Bamber subbed for Matt Campbell in the #911 Porsche GT Team entry due to a clash with the GT World Challenge Europe round at Circuit Paul Ricard. In GTD, Marc Miller subbed for Ben Keating in the Riley Motorsports entry due to a clash with the FIA World Endurance Championship round at Bahrain. Joey Hand subbed for Álvaro Parente in the #57 Heinricher Racing with MSR Curb-Agajanian. Nick Yelloly subbed for Bill Auberlen in the Turner Motorsport entry due to quarantine. GRT Grasser Racing Team made their first appearance since the TireRack.com Grand Prix at Road Atlanta. Pierre Kaffer joined Andrew Davis and Robert Ferriol in the Team Hardpoint entry.

There were three practice sessions preceding the start of the race on Saturday, all three were on Thursday. The first session held Thursday morning lasted one hour. The second session held Thursday afternoon lasted 75 minutes. The final session held Thursday evening lasted 90 minutes.

The first practice session took place at 10:05 am ET on Thursday and ended with Hélio Castroneves topping the charts for Acura Team Penske, with a lap time of 1:49.360. Simon Trummer was fastest in LMP2 with a time of 1:52.040. Frédéric Makowiecki set the fastest time in GTLM with a time of 1:58.717. The GTD class was topped by the #14 AIM Vasser Sullivan Lexus RC F GT3 of Jack Hawksworth with a lap time of 2:02.961.

The second practice session took place at 2:35 pm ET on Thursday and ended with Renger van der Zande topping the charts for Konica Minolta Cadillac, with a lap time of 1:47.478. Mikkel Jensen set the fastest time in LMP2. The GTLM class was topped by the #912 Porsche GT Team Porsche 911 RSR-19 of Laurens Vanthoor with a time of 1:57.975. Frédéric Makowiecki was second in the #911 Porsche GT Team car and Jordan Taylor rounded out the top 3. The GTD class was topped by the #11 GRT Grasser Racing Team Lamborghini Huracán GT3 Evo of Steijn Schothorst with a time of 2:02.352.