| 2021 Christus Health Pro Challenge | |
|---|---|
| Date | 25–31 October 2021 |
| Edition | 5th |
| Category | ITF Women's World Tennis Tour |
| Prize money | $80,000 |
| Surface | Hard |
| Location | Tyler, Texas, United States |
| Champions | |
| Singles | |
 Misaki Doi | |
| Doubles | |
 Giuliana Olmos / Marcela Zacarías | |
The 2021 Christus Health Pro Challenge was a professional women's tennis tournament played on outdoor hard courts. It was the fifth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Tyler, Texas, United States between 25 and 31 October 2021.[1]
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 USA
|
Madison Brengle | 78 | 1 |
| USA
|
Claire Liu | 88 | 2 |
 BRA
|
Beatriz Haddad Maia | 94 | 3 |
| JPN
|
Misaki Doi | 106 | 4 |
 GBR
|
Harriet Dart | 134 | 5 |
 CHN
|
Wang Xiyu | 140 | 6 |
| USA
|
Caty McNally | 141 | 7 |
 POL
|
Katarzyna Kawa | 159 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Misaki Doi def. Harriet Dart, 7–6(7–5), 6–2 Giuliana Olmos / Marcela Zacarías def. Misaki Doi / Katarzyna Kawa, 7–5, 1–6, [10–5]
