The 2021 MotoE World Cup (known officially as the 2021 FIM Enel MotoE World Cup for sponsorship reasons) was the third season of the MotoE World Cup for electric motorcycle racing, and was a support series of the 73rd F.I.M. Grand Prix motorcycle racing season.

The Cup was won by Spanish rider Jordi Torres for the second consecutive season at the final round in Misano.

All teams used the series-specified Energica Ego Corsa.

On weekends with two races, the E-Pole qualifying session would determine the starting grid for both races. Previously, the starting grid for the second race was based on the results of the first race.

The 2021 MotoE provisional calendar was released on 11 November 2020, featuring 7 races at 6 venues, supporting the Spanish, French, Catalan, Dutch, Austrian and San Marino Grand Prix—the latter being a double header.

Points were awarded to the top fifteen finishers. A rider had to finish the race to earn points.