| 2021 Orlando Open II | |
|---|---|
| Date | 7–13 June |
| Edition | 4th |
| Surface | Hard |
| Location | Orlando, Florida, United States |
| Champions | |
| Singles | |
 Christopher Eubanks | |
| Doubles | |
Christian Harrison /  Peter Polansky | |
The 2021 Orlando Open II was a professional tennis tournament played on hard courts. It was the fourth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Orlando, Florida, United States between 7 and 13 June 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 JPN
|
Yasutaka Uchiyama | 115 | 1 |
 TPE
|
Jason Jung | 160 | 2 |
| USA
|
Jenson Brooksby | 163 | 3 |
 ITA
|
Paolo Lorenzi | 167 | 4 |
 ECU
|
Emilio Gómez | 179 | 5 |
| USA
|
Ernesto Escobedo | 188 | 6 |
 ARG
|
Guido Andreozzi | 200 | 7 |
| USA
|
Mitchell Krueger | 207 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Christopher Eubanks def. 
Nicolás Mejía 2–6, 7–6(7–3), 6–4. Christian Harrison / Peter Polansky def. JC Aragone / Nicolás Barrientos 6–2, 6–3.
