The 2022 Berlin Marathon was the 48th edition of the annual marathon race in Berlin, which took place on Sunday, 25 September 2022. An Elite Platinum Label marathon, it was the first of four World Marathon Majors events to be held over the span of six weeks. 45,527 runners with 34,879 finishers from 157 countries have taken part in the event.

Kenyan runner Eliud Kipchoge set a new marathon world record, winning the race with a time of 2:01:09, and beating the previous record, which he had set himself four years prior in Berlin, by 30 seconds. This was Kipchoge's fourth victory at the Berlin Marathon, making him the second runner to win the race four times, after Ethiopian runner Haile Gebrselassie.

Ethiopian runner Tigist Assefa won the race with a time of 2:15:37, setting a new course record in Berlin with her second marathon race. Assefa's time was also the third-fastest woman's marathon time ever, and broke her personal record by over 18 minutes. She would go on to break this record the following year, when she set a new world record.

Swiss wheelchair athlete Marcel Hug claimed his seventh Berlin Marathon victory with a time of 1:24:56, while another Swiss wheelchair athlete, Catherine Debrunner, won the race with a time of 1:36:47 in her marathon debut.

Kenyan runner Eliud Kipchoge entered as the pre-race favorite. Before the race, he was the holder of the marathon world record, which he had set with a finish time of 2:01:39 four years prior at the 2018 Berlin Marathon. Kipchoge's 2022 win made him the second runner to have won the Berlin Marathon four times, after Ethiopian runner Haile Gebrselassie.

Also competing was Ethiopian runner Guye Adola, the defending champion, who had won the previous year's marathon with a time of 2:05:45. The 2017 Berlin Marathon was Adola's marathon debut, where he finished with a time of 2:03:46, the fastest marathon debut ever at the time. That year, Adola came in second to Kipchoge, who won with a time of 2:03:32.

Prior to this race, Ethiopian runner Tigist Assefa had run only one other marathon, the inaugural Riyadh Marathon earlier in March, which she had finished with a time of 2:34:01. Assefa had previously largely specialized in 800-metre races during her running career. During the summer, Assefa had run a number of 10,000-metre track races before focusing her attention back on marathon training. Keira D'Amato, holder of the U.S. record for the marathon, and Kenyan runner Vibian Chepkirui, winner of the 2022 Vienna City Marathon, also ran the race. D'Amato had won the 2022 Houston Marathon with a time of 2:19:12 to set the U.S. record. In addition, Kenyan runner Rosemary Wanjiru debuted at the marathon distance with this race.

Also competing were Swiss wheelchair athlete Marcel Hug, winner of the 2021 Tokyo Marathon; U.S. wheelchair athlete Daniel Romanchuk, winner of the 2022 Boston Marathon; and Swiss wheelchair athlete Manuela Schär, winner of the previous five Berlin Marathons. Swiss wheelchair athlete Catherine Debrunner, the reigning Paralympic champion in the women's T53 400-metre race, also made her marathon debut in this race.