The 2022 Hun Sen Cup was the 16th season of the Hun Sen Cup, the premier knockout tournament for association football clubs in Cambodia involving Cambodian Premier League, Cambodian League 2 and provincial football clubs organized by the Football Federation of Cambodia (FFC). The competition was split into 2 stages, the provincial stage which started on 8 February 2022 and the national stage with the top four teams from provincial stage entering the play-off of national stage, competing with the teams from Cambodian League 2.

Visakha were the defending champions and successfully defended their title, winning their record-extending 3rd consecutive and overall titles on 6 November.

Each group was played on a double round-robin basis at the pre-selected hosts. Group winners and runners-up advanced to Provincial quarter-finals.

Kampot won 4-3 on aggregate.

Phnmom Penh Galaxy won 7-1 on aggregate.

Uddor Meanchey won on penalties.

Ritthysen won 4-1 on aggregate.

Uddor Meanchey won 5-3 on aggregate .