The 2022 Nottingham Open (also known as the Rothesay Open Nottingham for sponsorship purposes) was a professional tennis tournament played on outdoor grass courts. It was the 14th edition of the event for women and the 26th edition for men. It was classified as a WTA 250 on the 2022 WTA Tour for the women, and as an ATP Challenger Tour event for the men. The event took place at the Nottingham Tennis Centre in Nottingham, United Kingdom from 6 through 12 June 2022.

This was Haddad Maia's maiden WTA Tour singles title.

The following players received wildcards into the main draw:

The following player received entry into the singles main draw as a special exempt:

The following player received entry into the singles main draw as an alternate:

The following players received entry from the qualifying draw:

The following players received wildcards into the main draw:

The following players received entry from the qualifying draw: