| 2022 Zagreb Open | |
|---|---|
| Date | 9–14 May 2022 |
| Edition | 18th |
| Surface | Clay |
| Location | Zagreb, Croatia |
| Champions | |
| Singles | |
 Filip Misolic | |
| Doubles | |
 Adam Pavlásek /  Igor Zelenay | |
The 2022 Zagreb Open was a professional tennis tournament played on clay courts. It was part of the 2022 ATP Challenger Tour. It took place in Zagreb, Croatia between 9 and 14 May 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 AUS
|
Jordan Thompson | 87 | 1 |
| AUS
|
Aleksandar Vukic | 128 | 2 |
| AUS
|
Christopher O'Connell | 129 | 3 |
 BIH |
|||
| CZE
|
Vít Kopřiva | 167 | 5 |
| AUS
|
Jason Kubler | 173 | 6 |
 ARG
|
Juan Pablo Ficovich | 182 | 7 |
 ITA
|
Federico Gaio | 183 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Filip Misolic def. 
Mili Poljičak 6–3, 7–6(8–6). Adam Pavlásek / Igor Zelenay def. Domagoj Bilješko / 
Andrey Chepelev 4–6, 6–3, [10–2].
