The 2024 Mexico City Open was a professional tennis tournament played on clay courts. It was the third edition of the tournament which was part of the 2024 ATP Challenger Tour. It took place in Mexico City, Mexico between 1 and 7 April 2024.

The following players received wildcards into the singles main draw:

The following players received entry into the singles main draw as special exempts:

The following players received entry from the qualifying draw: