The 2025 Michigan State Spartans baseball team represented Michigan State University in the 2025 NCAA Division I baseball season. The Spartans were led by head coach Jake Boss in his seventeenth season. The Spartans were members of the Big Ten Conference and played their home games at Jeff Ishbia Field at McLane Stadium in East Lansing, Michigan.

The Spartans finished the 2024 season 24–27, including 11–13 in conference play, finishing in tenth place in their conference. They failed to make the BIG 10 Tournament and did not receive a bid to the NCAA Tournament.

The Spartans began their season in Cary, North Carolina, at the USA Baseball National Training Complex. They defeated Western Michigan twice to open their season in a 7-inning double header on February 14th. Spartan ace Joseph Dzierwa threw incredibly well, going 6 innings, allowing 0 runs, and striking out 11. The Spartans went on to play Monmouth University in a doubleheader on February 15. Taking both games and beginning their season 4-0.

*Denotes non–conference game • source • Rankings based on the teams' current ranking in the D1 Baseball Poll • Game is in EST • . |}