The 2025 USC Trojans baseball team will represent the University of Southern California (USC) during the 2025 NCAA Division I baseball season. Due to Dedeaux Field being renovated the Trojans played their home games OC Great Park Baseball Complex, and Page Stadium in Los Angeles. The team will be coached by Andy Stankiewicz in his 3rd season at USC.

The Trojans ended the 2024 season with a record of 17–12 in conference play and 31–28 overall record, good for 4th place in the Pac-12. They would play in the Pac-12 tournament as the #4 Seed on Pool C in Game 1 they would beat Utah and then in Game 2 would beat Oregon they would play in the Semifinals beating #6 seed California and then they would play in the Championship Game against #1 seed Arizona but would lose to Arizona and would end their season after not being accepted into the 2024 NCAA Division I baseball tournament.

The Trojans had five players drafted in the 2024 MLB draft. Italics = did not sign.

† NCBWA ranks 30 teams in their preseason poll, but only ranks 25 teams weekly during the season.
* A new poll was not released for this week, so for comparison purposes, the previous week's ranking is inserted in this week's slot.