The 2025 USF Pro 2000 Championship presented by Continental Tire was the 27th season of the junior series two levels below the IndyCar series. It was the third season under the USF Pro 2000 moniker after the championship's most recent rebrand in 2023.

Pabst Racing's Max Garcia claimed the Drivers' Championship with three races to spare, while his team defended their Teams' Championship title for the third year in a row.

All drivers competed using Tatuus IP-22 racecars with Elite Mazda 2.0-014A engines and Continental tires.

BN Racing, which only returned to competition in the series in 2024, did not confirm its presence in the 2025 championship or any driver signings ahead of the season and did not enter any rounds.

Reigning Teams' Champions Pabst Racing took on three new drivers as Jace Denmark moved to TJ Speed Motorsports and Simon Sikes and Christian Brooks left the championship. Reigning USF2000 Champion Max Garcia remained with the team for his move up to USF Pro 2000, while Jacob Douglas returned to Pabst, with whom he came sixth in USF2000 in 2023. Michael Costello, the only newcomer to the Pabst Racing fold, stepped up to USFP2000 after coming ninth in USF2000 with JHDD to complete the team's lineup.

Only one of Turn 3 Motorsport's five drivers remained in the series as Drivers' Champion Lochie Hughes graduate to Indy NXT with Andretti Global, Danny Dyszelski left the team and Adam Fitzgerald and Ethan Ho had already departed mid-way through the 2024 season. Alessandro de Tullio, who entered six races with BN Racing in 2024, replaced Hughes in the No. 44 car, while Cooper Becklin, who entered nine races with TJ Speed Motorsports in 2024, piloted the No. 2 car. Two more drivers joined the team for the first race weekend in Titus Sherlock, who moved over from FR Americas after coming fourth in 2024 driving for Crosslink Kiwi Motorsports, and Elliot Cox, who stepped up from USF2000 after finishing sixth driving for Sarah Fisher Hartman Racing Development.

Velocity Racing Development's Nikita Johnson moved to GB3, where he joined Hitech Grand Prix, while also taking on a part-time Indy NXT campaign with HMD Motorsports. To replace him, VRD promoted Max Taylor after he won the USF Juniors title and came third in USF2000 in 2024 with the team. Eurocup-3 race winner Owen Tangavelou also joined the team for the opening two rounds of the season.

TJ Speed Motorsports took on three new drivers for their three cars. The No. 27 car previously occupied by Hunter Yeany before his mid-season departure was piloted by Formula Regional Japanese runner-up Sebastian Manson on his USFP2000 debut. Turn 3-bound Cooper Becklin, who spent the second half of the 2024 season in the team's No. 28 car, was replaced by Ariel Elkin, who jumped up from USF Juniors after finishing the 2024 season in fourth driving for International Motorsport. Liam Sceats joined HMD Motorsports for a part-time Indy NXT campaign, and USF2000 driver Evagoras Papasavvas was initially announced to replace him in the No. 28 car. Ahead of the season opener, Jace Denmark was instead announced to be the third driver in TJ Speed's lineup, returning to USFP2000 where he finished third in 2024 with Papst Racing after being unable to secure a drive in Indy NXT.