The 22nd Academy Awards were held on March 23, 1950, at the RKO Pantages Theatre, honoring the films in 1949. This was the final year in which all five Best Picture nominees were in Black & White, and the first year in which every film nominated for Best Picture won multiple Oscars.

All the King's Men became the first of two films to date to win Best Picture and two acting Oscars, yet lose Best Director (the other being Shakespeare in Love (1998)). This year marked the only occasion to date of two films each receiving two acting nominations within the same category: both Pinky and Come to the Stable received two nominations for Best Supporting Actress (Ethel Barrymore and Ethel Waters, and Celeste Holm and Elsa Lanchester, respectively). A Chance to Live and So Much for So Little's joint win in the Best Documentary (Short Subject) category marked the second occurrence of a tie in Oscar history.

Nominees were announced on February 12, 1950. Winners are listed first and highlighted in boldface.