The 22nd Game Developers Choice Awards was an annual ceremony by Game Developers Choice Awards for outstanding game developers and video games which was held on March 23, 2022. The awards ceremony was held alongside the Independent Games Festival awards.

Nominees were announced on January 11, 2022. Winners (noted in bold below) were named on March 23, 2022 in a ceremony hosted by Leslee Sullivant at the Moscone Center.

Yuji Horii, creator of the Dragon Quest series

Steven Spohn, founder of AbleGamers