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4C-B

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4C-B

4C-B, also known as 4C-DOB or DOB-B, as well as 4-bromo-2,5-dimethoxy-α-ethylphenethylamine, is a lesser-known psychedelic drug of the phenethylamine, phenylisobutylamine, and 4C families related to 2C-B (the 2C analogue) and DOB (the DOx analogue). It is a reasonably potent 5-HT2A receptor partial agonist with a Ki of 7.6 nM, but has relatively low efficacy (15% relative to 5-HT). It is briefly mentioned in Alexander Shulgin's 1991 book PiHKAL (Phenethylamines I Have Known And Loved), but was never tested by Shulgin. Subsequently, the drug was tested by Daniel Trachsel and colleagues, and was found to be active in a dose range of 50 to 80 mg with a duration of around 8 hours. It produced pronounced psychedelic effects, though with generally milder effects than 2C-B or DOB.

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