5-MeO-PiPT, also known as 5-methoxy-N-propyl-N-isopropyltryptamine, is a substituted tryptamine derivative which is claimed to have psychedelic effects. It has been sold as a designer drug, first being identified in 2021 in British Columbia, Canada.

5-MeO-PiPT was not included or mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).

5-MeO-PiPT acts as a serotonin 5-HT_1A and 5-HT_2A receptor agonist, with an EC₅₀Tooltip half-maximal effective concentration of 13.8 nM and an efficacy of 89%.

Analogues of 5-MeO-PiPT include propylisopropyltryptamine (PiPT), 4-HO-PiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MeO-DiPT, 5-MeO-MiPT, 5-MeO-EiPT, and 5-MeO-iPALT (ASR-3001), among others.