The 52nd Annual Annie Awards honoring excellence in the field of animation of 2024 was held on February 8, 2025, at the University of California, Los Angeles's Royce Hall in Los Angeles, California, presenting awards in 32 competitive categories as well as four juried special awards.

Nominees were revealed on December 20, 2024. DreamWorks Animation's The Wild Robot, directed by Chris Sanders and adapted from the novel by Peter Brown, led the nominations with 10, followed by Inside Out 2 and Wallace & Gromit: Vengeance Most Fowl, both with seven apiece. In the television categories, Netflix series Arcane, based on the Riot Games multiplayer video game League of Legends, led with seven nominations, followed by Dream Productions with six and Tales of the Teenage Mutant Ninja Turtles with five.

During the ceremony, two fire alarms were set off forcing everyone to leave the building and the live show was delayed for minutes.