Acjacheme ("a heap of animated things") was an Acjachemen village that was closely situated to the mother village of Putuidem in what is now San Juan Capistrano, California. The Spanish missionaries constructed Mission San Juan Capistrano less than 60 yards from the village in 1776. Acjachemen is a pluralization of the word Acjacheme, and became the moniker for the people overall after the mission period.

The village has also been referred to as Akhachmai, Ahachmai, Akagchemem, Acágcheme, and Axatcme. The village site has been identified as being at an elementary school east of the Mission San Juan Capistrano by José de Grácia Cruz, who was one of the last native people born at the mission in the 1840s. Ahachmai has been referred to as a dialect or variety of the Acjachemen language and is used, although less commonly, to refer to the people as a whole.

Gerónimo Boscana noted that the village "was later ruled by a relative called Choqual," who also was the leader of Putuidem. The village here was referred to as Atoum-pumcaxque, which was the village of Ahachmai. Choqual was a relative of Chief Oyaison, who came from Sejat, and his daughter Coronne.

The Portolá expedition encountered the village in 1769. With the establishment of Mission San Juan Capistrano in 1778 next to the village, the mission was dependent on local villagers for labor.

Boscana, who was stationed at Mission San Juan Capistrano between 1814 and 1826, noted the following of the village:

...the Indians, on returning home, arrived and put up for the night at a place called Acagchemen, distant from where the mission now stands only about sixty yards. From this time, the new colony assumed the name corresponding to the place. Acagchemen signifies a pyramidal form of anything that moves, such as an anthill or place of resort for other insects.

The population of Acjacheme may have declined after the establishment of Mission San Juan Capistrano in 1776. Many of the villagers were likely converted to Christianity shortly after the mission's founding. By 1810, there were 1,138 native converts at the mission. The San Juan Capistrano earthquake of 1812 collapsed a stone church built by "neophytes," with most of the casualties being Acjachemen women, likely from nearby villages.

By the time of the secularization of the mission in 1833, 4,317 Acjachemen and other native people had been baptized at the mission (1,689 adults and 2,628 children). The number of deaths at the mission was 3,158—probably mostly Acjachemen. Those who survived living at the mission often settled in the surrounding area afterward, possibly including Acjacheme.