Mesonychia ("middle claws") is an extinct taxon of small to large-sized carnivorous ungulates related to artiodactyls. Mesonychians first appeared in the Early Paleocene, went into a sharp decline at the end of the Eocene, and died out entirely when the last genus, Mongolestes, became extinct in the Early Oligocene. In Asia, the record of their history suggests they grew gradually larger and more predatory over time, then shifted to scavenging and bone-crushing lifestyles before the group became extinct.

Mesonychians probably originated in China, where the most primitive mesonychian, Yantanglestes, is known from the early Paleocene. They were also most diverse in Asia, where they occur in all major Paleocene faunas. Since other predators, such as creodonts and Carnivora, were either rare or absent in these animal communities, mesonychians most likely dominated the large predator niche in the Paleocene of eastern Asia.

One genus, Dissacus, had successfully spread to Europe and North America by the early Paleocene. Dissacus was a jackal-sized predator that has been found all over the Northern Hemisphere, but species of a closely related or identical genus, Ankalagon, from the early to middle Paleocene of New Mexico, were far larger, growing to the size of a bear. A later genus, Pachyaena, entered North America by the earliest Eocene, where it evolved into species that were at least as large. Mesonychians in North America were by far the largest predatory mammals during the early Paleocene to middle Eocene.

Mesonychians have often been reconstructed as resembling wolves albeit superficially, but they would have appeared very different in life. With a short lower spine stiffened by revolute joints, they would have run with stiff backs like modern ungulates rather than bounding or loping with flexible spines like modern carnivorans. While later mesonychians evolved a suite of limb adaptations for running similar to those in both wolves and deer, their legs remained comparatively thick. They would have resembled no group of living animals. Early mesonychians probably walked on the flats of their feet (plantigrade), while later ones walked on their toes (digitigrade). These later mesonychians had hooves, one on each toe, with four toes on each foot. The foot was compressed for efficient running with the axis between the third and fourth toes (paraxonic); it would have looked something like a hoofed paw.

Mesonychians varied in size; some species were as small as a fox. Although some species approached the size of moderately sized bears. Some members of the group are known only from skulls and jaws, or have fragmentary postcranial remains. But where skeletons are known, they indicate that mesonychians had large heads with strong jaw muscles, relatively long necks, and robust bodies with robust limbs that could run effectively but not rotate the hand or reach out to the side. An unrelated early group of mammalian predators, the creodonts, also had unusually large heads and limbs that traded flexibility for efficiency in running; large head size may be connected to inability to use the feet and claws to help catch and process food, as many modern carnivorans do. Some mesonychians are reconstructed as predatory (comparable to canids), others as scavengers or carnivore-scavengers with bone-crushing adaptations to their teeth (comparable to the large hyenas), and some as omnivorous (comparable to pigs, humans, or black bears). They may not have included hypercarnivores (comparable to felids); their teeth were not as effective at cutting meat as later groups of large mammalian predators. In some localities, multiple species or genera coexisted in different ecological niches. There is evidence to suggest that some genera were sexually dimorphic.

These "wolves on hooves" were probably one of the more important predator groups in the late Paleocene and Eocene ecosystems of Europe (which was an archipelago at the time), Asia (which was an island continent), and North America. Mesonychian dentition consisted of molars modified to generate vertical shear, thin blade-like lower molars, and carnassial notches, but no true carnassials.

The largest species are considered to have been scavengers.

Mesonychians were long considered to be creodonts, but have now been removed from that order and placed in three families (Mesonychidae, Hapalodectidae, and Triisodontidae), either within their own order, Mesonychia, or within the order Condylarthra as part of the cohort or superorder Laurasiatheria. Nearly all mesonychians are, on average, larger than most of the Paleocene and Eocene creodonts and miacoid carnivorans.