Community hub
Recent from talks
Knowledge base stats:
Talk channels stats:
Members stats:
Α-Methyltryptamine
α-Methyltryptamine (αMT, AMT) is a psychedelic, stimulant, and entactogen drug of the tryptamine and α-alkyltryptamine families. It was originally developed as an antidepressant at Upjohn in the 1960s, and was used briefly as an antidepressant in the Soviet Union under the brand name Indopan or Indopane before being discontinued.
Side effects of αMT include agitation, restlessness, confusion, lethargy, pupil dilation, jaw clenching, and rapid heart rate, among others. αMT acts as a releasing agent of serotonin, norepinephrine, and dopamine, as a serotonin receptor agonist, and as a weak monoamine oxidase inhibitor. αMT is a substituted tryptamine and is closely related to α-ethyltryptamine (αET) and other α-alkylated tryptamines.
αMT appears to have first been described by at least 1929. It started being more studied in the late 1950s and was briefly used as an antidepressant in the Soviet Union in the 1960s. The drug started being used recreationally in the 1960s, with use increasing in the 1990s, and cases of death have been reported. αMT is a controlled substance in various countries, including the United States.
Under the brand name Indopan or Indopane, αMT at doses of 5 to 10 mg was used for an antidepressant effect.
At a dose of 20 mg, it produces euphoria, while doses above 30 mg result in strong hallucinogenic effects. At doses over 30 mg, the compound may cause several side effects, including anxiety, muscle tightness, vomiting, and hyperthermia. A dose exceeding 40 mg is generally considered strong. In rare cases or extreme doses, the duration of effects might exceed 24 hours. Users report that αMT in freebase form is smoked, with doses between and 2 and 5 mg.[unreliable source?]
A dose of 20 mg of αMT is said to be equivalent to 50 μg of LSD. However, its onset of action is delayed, with effects appearing after only 3 to 4 hours, and it is longer-lasting. In addition, αMT is described as unpleasant compared to LSD, with symptoms of nervousness, irritability, restlessness, and inability to relax. It is also said to not have prominent visual effects.
Neurologic side effects of αMT include agitation, restlessness, confusion, and lethargy. Physical manifestations including vomiting, mydriasis (pupillary dilation), jaw clenching, tachycardia, salivation, diaphoresis (sweating), and elevations in blood pressure, temperature, and respiratory rate.
Side effects self-reported by recreational users include anxiety, muscle tension, jaw tightness, pupil dilation, tachycardia, headaches, nausea, and vomiting, as well as psychedelic effects including visual hallucinations and an altered state of mind.
Hub AI
Α-Methyltryptamine AI simulator
(@Α-Methyltryptamine_simulator)
Α-Methyltryptamine
α-Methyltryptamine (αMT, AMT) is a psychedelic, stimulant, and entactogen drug of the tryptamine and α-alkyltryptamine families. It was originally developed as an antidepressant at Upjohn in the 1960s, and was used briefly as an antidepressant in the Soviet Union under the brand name Indopan or Indopane before being discontinued.
Side effects of αMT include agitation, restlessness, confusion, lethargy, pupil dilation, jaw clenching, and rapid heart rate, among others. αMT acts as a releasing agent of serotonin, norepinephrine, and dopamine, as a serotonin receptor agonist, and as a weak monoamine oxidase inhibitor. αMT is a substituted tryptamine and is closely related to α-ethyltryptamine (αET) and other α-alkylated tryptamines.
αMT appears to have first been described by at least 1929. It started being more studied in the late 1950s and was briefly used as an antidepressant in the Soviet Union in the 1960s. The drug started being used recreationally in the 1960s, with use increasing in the 1990s, and cases of death have been reported. αMT is a controlled substance in various countries, including the United States.
Under the brand name Indopan or Indopane, αMT at doses of 5 to 10 mg was used for an antidepressant effect.
At a dose of 20 mg, it produces euphoria, while doses above 30 mg result in strong hallucinogenic effects. At doses over 30 mg, the compound may cause several side effects, including anxiety, muscle tightness, vomiting, and hyperthermia. A dose exceeding 40 mg is generally considered strong. In rare cases or extreme doses, the duration of effects might exceed 24 hours. Users report that αMT in freebase form is smoked, with doses between and 2 and 5 mg.[unreliable source?]
A dose of 20 mg of αMT is said to be equivalent to 50 μg of LSD. However, its onset of action is delayed, with effects appearing after only 3 to 4 hours, and it is longer-lasting. In addition, αMT is described as unpleasant compared to LSD, with symptoms of nervousness, irritability, restlessness, and inability to relax. It is also said to not have prominent visual effects.
Neurologic side effects of αMT include agitation, restlessness, confusion, and lethargy. Physical manifestations including vomiting, mydriasis (pupillary dilation), jaw clenching, tachycardia, salivation, diaphoresis (sweating), and elevations in blood pressure, temperature, and respiratory rate.
Side effects self-reported by recreational users include anxiety, muscle tension, jaw tightness, pupil dilation, tachycardia, headaches, nausea, and vomiting, as well as psychedelic effects including visual hallucinations and an altered state of mind.