Altoona-style pizza is a distinct type of pizza created in the city of Altoona, Pennsylvania, by the Altoona Hotel. The definitive characteristics of Altoona-style pizza are a Sicilian-style pizza dough, tomato sauce, sliced green bell pepper, salami, topped with American cheese and pizzas cut into squares instead of wedges.

The crust is made of a Sicilian-style pizza dough, giving the pie a thick and soft crust. Instead of the larger pie-like wedges typical of many pizza styles, Altoona Hotel pizza is typically cut into squares.

While originally topped with Velveeta, Altoona-style pizza is popularly topped with yellow processed cheese known as American cheese. The yellow squares of American cheese are a staple of this dish, used instead of the mozzarella or provolone common to other styles of pizza.

The traditional toppings included on a slice of Altoona-style pizza are a sliced green bell pepper and cooked deli style salami with peppercorns, notable for being underneath the pizza's cheese topping.

Altoona-style pizza originated at the Altoona Hotel in the 1950s. The hotel was noted as serving "a unique pizza" in 1996 by the Pittsburgh Post-Gazette. Following the destruction of the hotel in 2013 by fire, other local restaurants began serving Altoona-style pizza.