Amazing Adult Fantasy, retitled Amazing Fantasy in its final issue, is an American comic book anthology series published by Marvel Comics from 1961 through 1962, with the latter title revived with superhero features in 1995 and in the 2000s. The final 1960s issue, Amazing Fantasy #15 (cover-dated Aug. 1962), introduced the popular Marvel superhero Spider-Man. Amazing Adult Fantasy premiered with issue #7, taking over the numbering from Amazing Adventures.

The science fiction-fantasy anthology Amazing Adult Fantasy began with issue #7 (cover-dated Dec. 1969), having taken over the number of the similar anthology Amazing Adventures. The earlier issues before the title change featured stories drawn by a number of artists including Jack Kirby, Don Heck and Steve Ditko. Amazing Adult Fantasy featured exclusively the quick, quirky, twist-ending tales of artist Ditko and writer-editor Stan Lee that had appeared in Amazing Adventures and sister titles primarily featuring rampaging monsters. The cover of the comic carried the motto "The magazine that respects your intelligence".

Lee in 2009 described these "short, five-page filler strips that Steve and I did together", originally "placed in any of our comics that had a few extra pages to fill", as "odd fantasy tales that I'd dream up with O. Henry-type [twist] endings". Giving an early example of what would later be known as the "Marvel Method" of writer-artist collaboration, Lee said: "All I had to do was give Steve a one-line description of the plot and he'd be off and running. He'd take those skeleton outlines I had given him and turn them into classic little works of art that ended up being far cooler than I had any right to expect".

With issue #15 (Aug. 1962) Amazing Adult Fantasy was retitled Amazing Fantasy. This issue's lead feature introduced the superhero Spider-Man, written by Lee and drawn by Ditko, although Lee rejected Ditko's cover art and commissioned Jack Kirby to pencil a cover that Ditko inked. As Lee explained in 2010: "I think I had Jack sketch out a cover for it because I always had a lot of confidence in Jack's covers". In numerous interviews Lee has recalled how the title had been slated for cancellation, and so with nothing to lose, publisher Martin Goodman reluctantly agreed to allow him to introduce Spider-Man, a new kind of superhero – one who would be a teenager, but not a sidekick, and one who would have everyman doubts, neuroses and money problems. However, while this was indeed the final issue, its editorial page anticipated the comic continuing and that "the Spiderman [sic] ... will appear every month in Amazing".

Regardless, sales for Amazing Fantasy #15 proved to be one of Marvel's highest at the time, so the company launched the series The Amazing Spider-Man seven months later.

The DVD release of the collector's edition of the Spider-Man film included a copy of Amazing Fantasy #15. In 2001, Marvel published the 10-issue historical overview The 100 Greatest Marvels of All Time, with Amazing Fantasy #15 topping the list.

In 2008, an anonymous donor gave the original 24 pages of Ditko art for Amazing Fantasy #15 to the Library of Congress, which included Spider-Man's debut and the stories "The Bell-Ringer", "Man in the Mummy Case", and "There Are Martians Among Us".

For decades, no attempts were made to relaunch the title or to continue it with an issue #16. However, in 1995, Marvel editor Danny Fingeroth decided a story gap existed between Amazing Fantasy #15 and The Amazing Spider-Man #1. In an attempt to fill that gap, Marvel published three Spider-Man flashback stories in Amazing Fantasy #16–18 (Dec. 1996 – March 1998), each written by Kurt Busiek and painted chiefly by Paul Lee.