Amy Smith's experiences and observations from working in developing countries likely led to the initial conceptualization of D-Lab. She recognized the need for a practical, hands-on approach to addressing challenges faced by communities in resource-limited settings.

Amy Smith founded the MIT D-Lab, a program focused on applying design and engineering principles to develop innovative solutions for poverty alleviation and global development challenges. This marked a significant step in formalizing her vision and creating a platform for students and researchers to engage in collaborative projects with communities around the world.

D-Lab experienced significant growth and expansion under Amy Smith's leadership. The program developed a diverse range of courses, workshops, and research initiatives focused on various areas, including water purification, energy access, agriculture, and healthcare. It facilitated numerous student projects and collaborations with international partners.

D-Lab continues to thrive as a prominent program at MIT, inspiring students and faculty to address global challenges through design, innovation, and community engagement. The program's impact extends far beyond the MIT campus, fostering a network of practitioners and researchers dedicated to creating sustainable and equitable solutions for a more just and prosperous world.