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Anal sinuses
Anal sinuses
Anal sinuses
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Anal sinuses
Coronal section of rectum and anal canal
The interior of the anal canal and lower part of the rectum, showing the anal columns and the anal valves between their lower ends (the columns were more numerous in the specimen than usual)
Details
Identifiers
Latinsinus anales
TA98A05.7.05.006
TA23013
FMA76584
Anatomical terminology

An anal sinus (rectal sinus) is a furrow formed between any two adjacent anal columns of the anal canal. An anal sinus is limited inferiorly by an anal valve (which unites the inferior ends of a pair of adjacent anal columns). The anal glands open into the anal sinuses.[1]

References

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Anal sinuses

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The anal sinuses, also known as sinuses of the , are small mucosal recesses or furrows located in the proximal portion of the , situated above the pectinate (dentate) line and formed between adjacent vertical folds called anal columns. These sinuses are bounded inferiorly by thin transverse folds of mucosa termed anal valves and extend into the , where they accommodate the openings of anal glands. They are lined by columnar epithelium continuous with that of the . The primary function of the anal sinuses is to house and facilitate the secretion from anal glands, which are branched tubular structures embedded in the that produce to lubricate the , aiding in the smooth passage of during and helping to maintain . These glands, numbering 3-12 in total, open into the base of the sinuses via ducts that traverse the , and their secretions contribute to the protective barrier against microbial invasion in the anorectal region. Clinically, the anal sinuses are significant due to their association with cryptoglandular ; obstruction or of the anal glands within the sinuses is the most common (accounting for about 95% of cases) of perianal abscesses and subsequent fistula-in-ano, often requiring surgical intervention such as or . These conditions can lead to chronic inflammation, scarring, and complications like if untreated, underscoring the sinuses' role in anorectal disease .

Anatomy

Location

The anal sinuses, also known as rectal sinuses or sinuses of Morgagni, are furrows or recesses formed between adjacent anal columns in the upper portion of the anal canal. They are positioned in the colorectal zone, which constitutes the proximal two-thirds of the anal canal, extending from the anorectal junction distally to the pectinate line. These sinuses are bounded inferiorly by the anal valves, which connect the lower ends of the anal columns and collectively form the irregular, zigzag pectinate (dentate) line. Typically, there are 6 to 10 anal sinuses, corresponding to the number of anal columns, and they span the upper , which measures approximately 2 to 2.5 cm in length within the overall 3 to 4 cm anal canal. Spatially, the anal sinuses lie within the mucosa overlying the internal anal sphincter, which forms the muscular wall of the upper anal canal, and are located immediately distal to the rectal ampulla at the anorectal junction. This positioning places them in close proximity to the submucosal layer, facilitating their integration into the overall architecture of the distal gastrointestinal tract.

Structure

The anal sinuses are pouch-like recesses formed between adjacent vertical folds of the rectal mucosa known as anal columns in the upper part of the . These structures are bounded superiorly by the anal columns and inferiorly by thin, crescentic folds called anal valves, creating shallow furrows that contribute to the irregular contour of the anal canal's luminal surface. The alignment of the anal valves along the inferior margin of these sinuses forms the pectinate (dentate) line, marking a key transitional boundary in the . The number of anal sinuses varies but typically corresponds to 6 to 10 anal columns. The ducts of the submucosal anal glands open into the bases of the anal sinuses (also known as anal crypts). The anal sinuses are situated within the of the and are closely related to vascular elements, including arteriovenous cushions that form part of the anal cushions—submucosal structures composed of vascular plexuses aiding in the canal's structural integrity. Neural elements, such as branches from the , provide visceral innervation to the region encompassing the sinuses above the , though specific neural associations with the sinuses themselves are not distinctly delineated beyond the general supply to the upper .

Histology

Epithelial lining

The anal sinuses are lined by , which is derived from the of the and maintains continuity with the mucosal lining of the . This epithelial type provides a glandular, secretory surface suited to the upper anal canal's environment. A key histological transition occurs at the , where the of the anal sinuses gives way inferiorly to non-keratinized . This demarcation reflects the embryological shift from endodermal to ectodermal origins and influences the canal's varying susceptibility to pathological processes. The itself is a single-layered structure, typically thin to facilitate absorption and , while the underlying mucosal folding into longitudinal anal columns creates the characteristic pouch-like depressions of the sinuses. These folds, joined inferiorly by transverse anal valves, enhance the sinuses' capacity to harbor and expand the surface area for epithelial coverage.

Glands and crypts

The anal glands are tubuloalveolar structures embedded within the of the , primarily in the transitional zone, and are responsible for secretion through their associated ducts. In humans, there are typically 6 to 12 such glands distributed around the anal circumference, with each featuring one or more slender ducts that measure 0.4 to 6 mm in length. These ducts open directly into the bases of the anal crypts, which lie at the lower extent of the anal sinuses. The anal crypts, also known as crypts of Morgagni, are shallow invaginations of the mucosa located at the junctions between the anal valves and the bases of the anal columns, forming the proximal boundaries of the anal sinuses. These crypts serve as the primary entry points for the ducts of the anal glands, with most crypts receiving one or more ductal openings, though approximately half may lack a gland connection in some individuals. The crypts are lined by transitional epithelium continuous with the walls of the anal sinuses, facilitating the integration of glandular secretions into the sinus lumen. Histologically, the anal glands consist of branching tubular ducts and acini lined by , interspersed with mucous cells that exhibit basally located nuclei and express mucins such as MUC5AC and MUC5B. The glandular acini form simple multicellular units, and approximately 25% of glands extend into the muscle, with others remaining submucosal or mucosal. In , anal glands are more prominent and complex in many animal species, such as carnivores and , where they often form larger sacs with secretions used for scent marking and territorial communication. In humans, these glands are rudimentary, lacking distinct sacs and primarily serving a lubricative role without significant odoriferous function.

Function

Mucus secretion

The anal sinuses facilitate the secretion of alkaline , primarily from goblet cells within the epithelial lining and from specialized anal glands embedded in the sinus walls, which coats the to provide lubrication and protection. This is produced by mucous cells in the glands, which release secretions rich in mucins to maintain a slippery barrier. The composition of this includes approximately 95% water, along with electrolytes such as sodium, , and , and glycoproteins known as mucins that confer and gel-like properties. In the anal region, these mucins predominantly consist of sialomucins (with N-acyl derivatives) and sulphomucins, contributing to the mucus's alkaline of around 7–8, which helps neutralize the slightly acidic of (average ~6.6). Secretion is regulated primarily through parasympathetic innervation via the , which stimulate glandular activity in response to neural signals from the . The ducts of these glands open into the bases of the anal crypts, as detailed in histological studies, ensure coordinated release. In the resting state, volume is minimal, sufficient only for baseline lubrication of the short , but it increases during preparation for to facilitate smooth passage of . This dynamic adjustment supports efficient function without excessive discharge under normal conditions.

Role in defecation

During defecation, the anal sinuses play a supportive role by providing to the , which reduces between the passing fecal matter and the canal walls. The glands within the anal sinuses secrete that coats the fecal bolus, enabling smoother through the canal as peristaltic waves from the advance the contents toward the . This mucus coating facilitates the overall mechanics of by providing lubrication that minimizes resistance during the relaxation of the , which occurs reflexively in response to rectal distension via the rectoanal inhibitory reflex. The lubrication minimizes resistance, allowing for more efficient opening and passage without excessive straining. Additionally, the anal sinuses contribute to the process in coordination with the puborectalis muscle and , which relax to straighten the anorectal angle and permit fecal expulsion; the ensures that this muscular relaxation translates into unobstructed flow through the canal. Unlike the anal sphincters and puborectalis muscle, the anal sinuses do not participate in fecal storage or the maintenance of continence, as their primary function is limited to secretory support during evacuation rather than tonic control or barrier formation.

Clinical significance

Infections and abscesses

The anal sinuses, which house the anal glands and their ducts opening from the crypts, serve as the primary entry points for infections in the anorectal region, initiating cryptoglandular abscesses. These infections typically arise when from the fecal stream penetrate the ducts of the glands embedded within the sinus walls, leading to localized suppuration. Common examples include perianal abscesses, which form superficially near the anal verge, and ischiorectal abscesses, which develop deeper in the ischiorectal fossae adjacent to the sinuses. The microbial profile of these abscesses is predominantly polymicrobial, reflecting the mixed enteric flora, with Escherichia coli and Bacteroides species (such as Bacteroides fragilis) identified as the most frequent pathogens. Risk factors that predispose individuals to infection include chronic constipation, which promotes gland obstruction through fecal impaction, and local trauma, such as from anal instrumentation or injury, which can facilitate bacterial ingress into the sinus ducts. Other contributing elements encompass obesity, diabetes mellitus, and smoking, which impair immune responses and tissue perfusion in the perianal area. Pathogenesis begins with blockage of the ducts within the sinuses, often due to debris or fecal material, causing stasis and bacterial overgrowth that progresses to acute suppuration. If untreated, the infection can extend beyond the sinus confines, spreading into adjacent intersphincteric spaces along potential planes of least resistance, potentially forming more complex collections. Cryptoglandular origins account for approximately 80-90% of anorectal in adults, underscoring the sinuses' central role in this prevalent condition.

Fistulas and surgical relevance

Anal fistulas of the cryptoglandular type typically develop as a chronic complication following the drainage of an intersphincteric originating from infected anal sinuses, where the internal opening of the fistula tract is located at the dental crypt of the sinus. This progression occurs in up to 40% of cases after surgical drainage and up to 66% after spontaneous rupture, as the persistent tracks through the wall. The fistulous tract forms a communication between the and the perianal skin, often leading to recurrent drainage and if untreated. Fistulas are classified primarily using Parks' system based on their relationship to the anal complex, with intersphincteric fistulas being the most common (50-80% of cases), followed by transsphincteric types that traverse the external . Less frequent are suprasphincteric and extrasphincteric variants, which involve more complex extensions above or outside the sphincters. aids in predicting the tract's course by relating the external opening's position to the internal opening: anterior external openings typically connect radially (straight) to the , while posterior ones curve toward the posterior midline. This rule, though useful for surgical planning, has variable accuracy, particularly for anterior or complex tracts. Surgical management prioritizes eradicating the tract while preserving sphincter function to minimize incontinence risk, especially in higher fistulas. Fistulotomy, involving incision and drainage of the tract with open healing, is the standard for low intersphincteric fistulas, achieving healing rates of approximately 94% with low continence impairment if the external sphincter is spared. For transsphincteric or complex cases, seton placement—using a draining or cutting thread to gradually divide the sphincter—offers up to 98% healing while maintaining continence. The ligation of the intersphincteric fistula tract (LIFT) procedure, which ligates the tract within the intersphincteric plane without dividing the sphincter, is particularly effective for transsphincteric fistulas, with success rates of 40-100% and minimal incontinence. Complete excision or addressing the originating anal gland during surgery is crucial to prevent persistence. Prognosis varies by fistula type and surgical completeness, with overall healing rates of 80% for simple fistulas and 60% for complex ones; recurrence occurs in 10-20% of cases if the internal opening or residual glandular tissue is not fully addressed. Factors increasing recurrence include multiple tracts or incomplete tract identification, potentially necessitating reoperation. In non-infectious chronic conditions unrelated to glandular , such as certain inflammatory diseases, anal sinuses carry low surgical relevance, as fistulization is uncommon without suppuration.

References

  1. https://www.ncbi.nlm.nih.gov/books/NBK557585/
  2. https://emedicine.medscape.com/article/1990236-overview
  3. https://link.springer.com/article/10.1007/BF02257784
  4. https://people.ohio.edu/witmerl/Downloads/Witmer-2006-04-25-Anorectal.pdf
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  6. https://www.ncbi.nlm.nih.gov/books/NBK554531/
  7. https://humananatomy.host.dartmouth.edu/BHA/public_html/part_6/chapter_36.html
  8. https://my.clevelandclinic.org/health/body/24784-anus-function
  9. https://www.kenhub.com/en/library/anatomy/the-anal-canal
  10. https://radiopaedia.org/articles/anal-columns
  11. https://pubmed.ncbi.nlm.nih.gov/22718291/
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  16. https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar.23748
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  20. https://www.ncbi.nlm.nih.gov/books/NBK545268/
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  22. https://anatomylab.class.virginia.edu/GI/Lab04/PowerPointHandout_MidgutHindgut.pdf
  23. https://pmc.ncbi.nlm.nih.gov/articles/PMC3266159/
  24. https://pmc.ncbi.nlm.nih.gov/articles/PMC11466523/
  25. https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/1688571/all/Anorectal_Abscess
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