Andre Dewayne Smith Jr. (born January 25, 1987) is an American former professional football player who was an offensive tackle in the National Football League (NFL). He played college football for the Alabama Crimson Tide, earning unanimous All-American honors in 2008. He was selected by the Cincinnati Bengals in the first round of the 2009 NFL draft with the sixth overall pick. He also played for the Minnesota Vikings, Arizona Cardinals, and Baltimore Ravens.

Smith was born in Birmingham, Alabama. He attended Huffman High School in Birmingham, where he played football and competed in track. In football, he was a three-year starter, a two-time All-State selection, and Class 6A Lineman of the Year in 2005. After registering 88 pancake blocks his senior season, Smith was selected "Mr. Football" by the Alabama Sports Writers Association, becoming the only offensive lineman to ever win the honor in the association's 23-year history. Smith earned High School All-American honors by USA Today and was selected to play in the 2006 U.S. Army All-American Bowl. He was also one of four finalists for the 2005 Walter Payton Trophy, given to the nation's most athletic high school football player.

In addition to football, Smith also participated in track and field at Huffman. As a senior in 2006, Smith competed in the throwing events at the State Track & Field Meet, where he registered throws of 14.81 meters (48'7.25") in the shot put and 39.62 meters in the discus throw (126'8") that earned him sixth and eleventh-place finishes, respectively.

Regarded as a five-star recruit by both Rivals.com and Scout.com, Smith was listed as the No. 1 offensive lineman by both recruiting services. Rivals described him as "one of the most dominant offensive line prospects in the last 10 years," and—after reevaluating their 2005–'09 rankings in February 2009—considered him the best offensive tackle prospect of that period. Mike Farrell of The Sporting News called Smith "the best offensive line prospect since Orlando Pace."

Smith attended the University of Alabama beginning in 2006. In 2006, he played for Coach Mike Shula (and Coach Joe Kines). In 2007 and 2008, he played for coach Nick Saban's Alabama Crimson Tide football teams. In his initial year at Alabama, he started all 13 games at left tackle, becoming only the fourth true freshman offensive lineman to start for the Crimson Tide. Smith played at least 65 snaps in 10 of 13 games and played more than 70 snaps five times, while leading the Crimson Tide with 62 pancake blocks. He also scored a touchdown off of a lateral in the 34–31 Independence Bowl loss against Oklahoma State. Smith earned Freshman All-American honors by the Football Writers Association of America.

In 2007, Smith was a first-team All-Southeastern Conference selection, after starting every game at the left tackle position. He was named Alabama Co-Player of the Week four times during the season.

Smith was recognized as a unanimous All-American in 2008, as well as the 2008 Outland Trophy winner. He was also considered to be one of the best underclassmen for the 2009 NFL draft. He was also a first-team All-SEC selection and shared the league's Jacobs Blocking Trophy with Arkansas center Jonathan Luigs. He led the team with 103 key knockdowns and added seven blocks downfield. He was penalized just twice and he allowed just one QB sack and six pressures on 334 pass plays.

On December 29, 2008, Smith was suspended from playing in the 2009 Sugar Bowl,—a game Alabama lost 31–17 to the Utah Utes—, reportedly because he dealt with an agent. A few days later, Smith declared himself eligible for the 2009 NFL draft, and at the time he was considered a lock to be a Top 5 pick.