Anna Cooke Kendrick was born in Portland, Maine, to Janice (née Cooke), an accountant, and William Kendrick, a history teacher who later worked in finance. She has an older brother, Michael Cooke Kendrick, who is also an actor.

Anna spent her childhood in Portland, Maine. From a young age, she displayed a passion for performing and began auditioning for stage roles in New York City. Her family strongly supported her ambitions, balancing her education with her burgeoning acting career.

Growing up, Anna showed an interest in theatre and performing arts. This passion would later lead her to pursue acting professionally. Her parents' encouragement was crucial during these formative years.